Tóm tắt

It has already been shown that sono-electrodeposition can be used to coat activated carbon fiber cloth (ACC)rnwith calcium phosphates (CaP) and we recently demonstrated that cathodic polarization at −1 V/Hg/Hg2SO4rnwas the best parameter to obtain a carbonated calcium deficient hydroxyapatite (CDA) coating with optimalrnuniformity and homogeneity. In the present study, we investigated whether this technique was suitable to dopernthis carbonated CDA coating by partial substitution with another bivalent cation such as strontium. We showrnhere that a strontium-substituted carbonated CDA coating can be produced and quantitatively controlled up to atrnleast 10 at.%. In this range we demonstrate that the presence of strontium does not modify either the textural orrnthe structural properties of the carbonated CDA. Owing to the well-known effect of both carbonated CDA andrnstrontium in bone formation, the biocompatibility of ACC coated or not with carbonated CDA or with strontiumrnsubstituted carbonated CDA was tested using primary human osteoblasts. Our data revealed a positive and dose-dependent effect of strontium addition on osteoblast activity and proliferation. In conclusion, we show here thatrnelectrodeposition at −1 V is a suitable and easy process to incorporate cations of biological interest into CaPrncoating.