Tóm tắt

Polymer membranes have been widely used in guided bone regeneration (GBR), especially when it comes torntheir use in dentistry. Poly (lactic acid) (PLA) have good mechanical properties such asflexibility, which allowsrnthe material to be moldable and also has biocompatibility and biodegradation. Besides that, bioglass (BG) in-corporated into the polymer matrix can promote osteoinduction properties and osteoconduction properties tornthe polymer-ceramic biocomposite. The membranes are also required to exhibit antimicrobial activity to preventrnor control the proliferation of pathogenic microorganisms, and the addition of carbon nanotubes (CNT) can assistrnin this property. The porous membranes of PLA with the addition of different contents of BG and CNT werernobtained by solvent casting in controlled humidity method, and the synergistic effect of the addition of bothrnfillers were investigated. The membranes showed pores (3–11μm) on their surface. The addition of 5 wt% BGrncauses an increase in the surface porosity and bioactivity properties of the PLA. The agar diffusion test showedrnantimicrobial activity in the membranes with addition of CNT.In vitroresults showed that the porous membranesrnwere not cytotoxic and allowed cell activity and differentiation. Thus, BG collaborated to increase biologicalrnactivity while CNT contributed to microbial activity, creating a synergistic effect on PLA porous membranes,rnbeing this effect more evident for PLA/5BG/1.0CNT. These results indicated a promising use of this new bio-material for the production of porous membranes for GBR