Trung tâm Thư viện và Tri thức số

Immunotherapy of Melanoma; Melanoma; 1 Melanoma-Introduction, History and Epidemiology; Abstract; 1.1 Introduction; 1.1.1 Basics of Structure and Functions of Skin; 1.1.2 Melanocytes; 1.1.3 Melanoma-Definition; 1.1.4 Prominent People Who Were Diagnosed with Melanoma; 1.2 History; 1.2.1 Initial Descriptions of Melanoma; 1.2.2 Hereditary Nature of Melanoma; 1.2.3 Descriptions of Uveal Melanoma; 1.2.4 Introduction of Term 'Melanoma'; 1.2.5 Descriptions of Association Between Melanoma and Skin Color; 1.2.6 Introduction of Clark's Level and Breslow Thickness.1.2.7 Descriptions of Associations Between Sunlight, MC1R Mutations and Melanoma1.2.8 Description of Familial Atypical Multiple Mole Melanoma and CDKN2A Mutations; 1.2.9 Discovery of Ras Oncogenes and Their Relationship with Melanoma; 1.2.9.1 Epidemiology; References; 2 Melanoma-Diagnosis, Subtypes and AJCC Stages; Abstract; 2.1 Introduction; 2.2 Signs and Symptoms of Melanoma; 2.3 Diagnosis; 2.3.1 Dermoscopy; 2.3.2 Total-Body Photography; 2.3.3 In Vivo Reflectance Confocal Laser Microscopy; 2.3.4 Histopathology; 2.3.5 Molecular Diagnosis; 2.4 Types of Melanoma. 2.4.1 Superficial Spreading Melanoma2.4.2 Lentigo Maligna Melanoma; 2.4.3 Acral Lentiginous Melanoma; 2.4.4 Nodular Melanoma; 2.4.5 Desmoplastic Melanoma; 2.4.6 Nevoid Melanoma; 2.4.7 Verrucous Melanoma; 2.5 Melanoma Stages; 2.5.1 Clark Classification; 2.5.2 Breslow Classification; 2.5.3 TNM (Tumor, Node and Metastasis) Classification; 2.5.4 Melanoma Staging-AJCC System; References; 3 Etiology; Abstract; 3.1 Introduction; 3.2 UV Light and Sun Exposure; 3.2.1 Sunlight Exposure and DNA Damage; 3.2.2 Repair of UV Induced DNA Damage; 3.2.3 Xeroderma Pigmentosum; 3.3 Family History. 3.4 Familial Atypical Multiple Mole Melanoma Syndrome3.5 Skin and Hair Color; 3.6 Susceptibility Genes; 3.6.1 Cyclin-Dependent Kinase Inhibitor 2A (CDKN2A); 3.6.2 Cyclin Dependent Kinase 4 (CDK4); 3.6.3 Melanocortin 1 Receptor (MC1R); 3.6.4 Microphthalmia-associated Transcription Factor (MITF); 3.7 Aberrant Signaling Pathways; 3.7.1 c-KIT or KIT; 3.7.2 RAS Family of Proteins; 3.7.3 BRAF Activation; References; 4 Melanoma-Treatment; Abstract; 4.1 Evolution of Treatment in 19th and 20th Centuries; 4.2 Surgery; 4.2.1 Primary Melanoma; 4.2.2 Regional Lymph Node Metastasis. 4.2.3 Metastatic Melanoma4.3 Adjuvant Therapy; 4.3.1 Adjuvant Immunotherapy; 4.3.2 Adjuvant Radiation Therapy; 4.4 Chemotherapy; 4.4.1 Alkylating Agents (Dacarbazine/Temozolomide); 4.4.2 Biochemotherapy; 4.5 Targeted Therapy; 4.5.1 BRAFV600E Inhibitors; 4.5.2 MEK Inhibitors; 4.6 Immunotherapy; 4.7 Recommendations (2013)€from Society of Immunotherapy of Cancer for Stage IV Melanoma; References; Tumor Immunology; 5 Overview of Immune System; Abstract; 5.1 Introduction; 5.2 Innate Immune System; 5.2.1 Neutrophils; 5.2.2 Complement System; 5.2.3 Eosinophils; 5.2.4 Mast Cells.

Loại tài liệu: Tài liệu số - Book

Thông tin trách nhiệm: Rotte, Anand; Bhandaru, Madhuri

Nhà Xuất Bản: Springer

Năm Xuất Bản: 2016

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Tóm tắt

This book focusses on the different types of immunotherapeutics that are currently being used and developed for the treatment of melanoma. In recent years, immunotherapy has revolutionized the treatment of metastatic melanoma and other types of cancer. Discussing treatment options for melanoma and the success of immunotherapy along with the challenges of immunotherapy, this book covers epidemiology, susceptibility genes, and treatment recommendations from Society for Immunotherapy of Cancer, as well as immune based therapies such as aldesleukin, Intron-A, Sylatron, Yervoy, Opdivo, Keytruda, Imlygic, DC vaccines and adoptive cell therapy. The detailed information included on the key immune cells involved in anti-tumor immune response and immune-inhibitory mechanisms in tumor microenvironment will aid the understanding of tumor immunology. Both academic as well as industry-based researchers, developing novel anti-cancer therapies, will also benefit from the details of promising molecular targets and immunotherapeutic strategies under investigation. With 132 illustrations including synopsis tables for important information, over 1200 references (majority of which are openly accessible) and details of more than 150 ongoing clinical trials, this book is a valuable source of information for health care providers as well as cancer biologists interested in learning about melanoma and the significant advances made by immunotherapy

Ngôn ngữ:	en
Thông tin trách nhiệm:	Rotte, Anand; Bhandaru, Madhuri
Thông tin nhan đề:	Immunotherapy of Melanoma; Melanoma; 1 Melanoma-Introduction, History and Epidemiology; Abstract; 1.1 Introduction; 1.1.1 Basics of Structure and Functions of Skin; 1.1.2 Melanocytes; 1.1.3 Melanoma-Definition; 1.1.4 Prominent People Who Were Diagnosed with Melanoma; 1.2 History; 1.2.1 Initial Descriptions of Melanoma; 1.2.2 Hereditary Nature of Melanoma; 1.2.3 Descriptions of Uveal Melanoma; 1.2.4 Introduction of Term 'Melanoma'; 1.2.5 Descriptions of Association Between Melanoma and Skin Color; 1.2.6 Introduction of Clark's Level and Breslow Thickness.1.2.7 Descriptions of Associations Between Sunlight, MC1R Mutations and Melanoma1.2.8 Description of Familial Atypical Multiple Mole Melanoma and CDKN2A Mutations; 1.2.9 Discovery of Ras Oncogenes and Their Relationship with Melanoma; 1.2.9.1 Epidemiology; References; 2 Melanoma-Diagnosis, Subtypes and AJCC Stages; Abstract; 2.1 Introduction; 2.2 Signs and Symptoms of Melanoma; 2.3 Diagnosis; 2.3.1 Dermoscopy; 2.3.2 Total-Body Photography; 2.3.3 In Vivo Reflectance Confocal Laser Microscopy; 2.3.4 Histopathology; 2.3.5 Molecular Diagnosis; 2.4 Types of Melanoma. 2.4.1 Superficial Spreading Melanoma2.4.2 Lentigo Maligna Melanoma; 2.4.3 Acral Lentiginous Melanoma; 2.4.4 Nodular Melanoma; 2.4.5 Desmoplastic Melanoma; 2.4.6 Nevoid Melanoma; 2.4.7 Verrucous Melanoma; 2.5 Melanoma Stages; 2.5.1 Clark Classification; 2.5.2 Breslow Classification; 2.5.3 TNM (Tumor, Node and Metastasis) Classification; 2.5.4 Melanoma Staging-AJCC System; References; 3 Etiology; Abstract; 3.1 Introduction; 3.2 UV Light and Sun Exposure; 3.2.1 Sunlight Exposure and DNA Damage; 3.2.2 Repair of UV Induced DNA Damage; 3.2.3 Xeroderma Pigmentosum; 3.3 Family History. 3.4 Familial Atypical Multiple Mole Melanoma Syndrome3.5 Skin and Hair Color; 3.6 Susceptibility Genes; 3.6.1 Cyclin-Dependent Kinase Inhibitor 2A (CDKN2A); 3.6.2 Cyclin Dependent Kinase 4 (CDK4); 3.6.3 Melanocortin 1 Receptor (MC1R); 3.6.4 Microphthalmia-associated Transcription Factor (MITF); 3.7 Aberrant Signaling Pathways; 3.7.1 c-KIT or KIT; 3.7.2 RAS Family of Proteins; 3.7.3 BRAF Activation; References; 4 Melanoma-Treatment; Abstract; 4.1 Evolution of Treatment in 19th and 20th Centuries; 4.2 Surgery; 4.2.1 Primary Melanoma; 4.2.2 Regional Lymph Node Metastasis. 4.2.3 Metastatic Melanoma4.3 Adjuvant Therapy; 4.3.1 Adjuvant Immunotherapy; 4.3.2 Adjuvant Radiation Therapy; 4.4 Chemotherapy; 4.4.1 Alkylating Agents (Dacarbazine/Temozolomide); 4.4.2 Biochemotherapy; 4.5 Targeted Therapy; 4.5.1 BRAFV600E Inhibitors; 4.5.2 MEK Inhibitors; 4.6 Immunotherapy; 4.7 Recommendations (2013)€from Society of Immunotherapy of Cancer for Stage IV Melanoma; References; Tumor Immunology; 5 Overview of Immune System; Abstract; 5.1 Introduction; 5.2 Innate Immune System; 5.2.1 Neutrophils; 5.2.2 Complement System; 5.2.3 Eosinophils; 5.2.4 Mast Cells.
Nhà Xuất Bản:	Springer
Loại hình:	Book
Bản quyền:	© Springer International Publishing AG 2016
Mô tả vật lý:	434 p.
Năm Xuất Bản:	2016