Tóm tắt

Osteogenic and angiogenic properties are two most valued factors for bone grafting materials. Biomedicalrnmaterials with synergistic promotion effects on these two properties would be highly desirable. In this study, wernshowed that a recently developed pH-neutral bioactive glass (PSC) possessed such characteristics. Compared torntwo classical biomaterials, 45S5 bioactive glass and beta-tricalcium phosphate (β-TCP), PSC markedly improvedrnBMSCs' proliferation, migration and mineralization as well as their osteogenic and angiogenic differentiation.Inrnvivo, PSC showed better performance on inducing bone regeneration than both 45S5 and β-TCP, as featured byrnelevated bone mineral density (BMD) and new bone areas. PSC also significantly promoted new blood vesselsrnformation compared with those in control groups. Furthermore, we revealed that PSC induced osteogenic andrnangiogenic differentiation of BMSCs through the PI3K/Akt/HIF-1αpathway, which had not been reported be-fore. This synergistic effect of the PI3K/Akt/HIF-1αpathway on osteogenesis and angiogenic differentiation ofrnBMSCs suggested that biomedical materials may promote new bone formation through multiple signal pathways,rnthus shedding light on the future development of materials with better performance