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Loại tài liệu: Tài liệu số - Book
Thông tin trách nhiệm: Leslie P. Willcocks; Chris SauerMary C. Lacity
Nhà Xuất Bản: Softcover reprint of the hardcover 1st edition 2016
Năm Xuất Bản: 2016
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This edited three volume edition brings together significant papers previously published in the Journal of information Technology (JIT) over its 30 year publication history. The three volumes of Enacting Research Methods in Information Systems celebrate the methodological pluralism used to advance our understanding of information technology's role in the world today. In addition to quantitative methods from the positivist tradition, JIT also values methodological articles from critical research perspectives, interpretive traditions, historical perspectives, grounded theory, and action research and design science approaches.rnrnVolume 1 covers Critical Research, Grounded Theory, and Historical Approaches. Volume 2 deals with Interpretive Approaches and also explores Action Research. Volume 3 focuses on Design Science Approaches and discusses Alternative Approaches including Semiotics Research, Complexity Theory and Gender in IS Research.rnrnThe Journal of Information Technology (JIT) was started in 1986 by Professors Frank Land and Igor Aleksander with the aim of bringing technology and management together and bridging the ‘great divide’ between the two disciplines. The Journal was created with the vision of making the impact of complex interactions and developments in technology more accessible to a wider audience. Retaining this initial focus, the JIT has gone on to extend into new and innovative areas of research such as the launch of JITTC in 2010. A high impact journal, JIT shall continue to publish leading trends based on significant research in the field.
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Melanoma; 1 Melanoma-Introduction, History and Epidemiology; Abstract; 1.1 Introduction; 1.1.1 Basics of Structure and Functions of Skin; 1.1.2 Melanocytes; 1.1.3 Melanoma-Definition; 1.1.4 Prominent People Who Were Diagnosed with Melanoma; 1.2 History; 1.2.1 Initial Descriptions of Melanoma; 1.2.2 Hereditary Nature of Melanoma; 1.2.3 Descriptions of Uveal Melanoma; 1.2.4 Introduction of Term 'Melanoma'; 1.2.5 Descriptions of Association Between Melanoma and Skin Color; 1.2.6 Introduction of Clark's Level and Breslow Thickness.1.2.7 Descriptions of Associations Between Sunlight, MC1R Mutations and Melanoma1.2.8 Description of Familial Atypical Multiple Mole Melanoma and CDKN2A Mutations; 1.2.9 Discovery of Ras Oncogenes and Their Relationship with Melanoma; 1.2.9.1 Epidemiology; References; 2 Melanoma-Diagnosis, Subtypes and AJCC Stages; Abstract; 2.1 Introduction; 2.2 Signs and Symptoms of Melanoma; 2.3 Diagnosis; 2.3.1 Dermoscopy; 2.3.2 Total-Body Photography; 2.3.3 In Vivo Reflectance Confocal Laser Microscopy; 2.3.4 Histopathology; 2.3.5 Molecular Diagnosis; 2.4 Types of Melanoma. 2.4.1 Superficial Spreading Melanoma2.4.2 Lentigo Maligna Melanoma; 2.4.3 Acral Lentiginous Melanoma; 2.4.4 Nodular Melanoma; 2.4.5 Desmoplastic Melanoma; 2.4.6 Nevoid Melanoma; 2.4.7 Verrucous Melanoma; 2.5 Melanoma Stages; 2.5.1 Clark Classification; 2.5.2 Breslow Classification; 2.5.3 TNM (Tumor, Node and Metastasis) Classification; 2.5.4 Melanoma Staging-AJCC System; References; 3 Etiology; Abstract; 3.1 Introduction; 3.2 UV Light and Sun Exposure; 3.2.1 Sunlight Exposure and DNA Damage; 3.2.2 Repair of UV Induced DNA Damage; 3.2.3 Xeroderma Pigmentosum; 3.3 Family History. 3.4 Familial Atypical Multiple Mole Melanoma Syndrome3.5 Skin and Hair Color; 3.6 Susceptibility Genes; 3.6.1 Cyclin-Dependent Kinase Inhibitor 2A (CDKN2A); 3.6.2 Cyclin Dependent Kinase 4 (CDK4); 3.6.3 Melanocortin 1 Receptor (MC1R); 3.6.4 Microphthalmia-associated Transcription Factor (MITF); 3.7 Aberrant Signaling Pathways; 3.7.1 c-KIT or KIT; 3.7.2 RAS Family of Proteins; 3.7.3 BRAF Activation; References; 4 Melanoma-Treatment; Abstract; 4.1 Evolution of Treatment in 19th and 20th Centuries; 4.2 Surgery; 4.2.1 Primary Melanoma; 4.2.2 Regional Lymph Node Metastasis. 4.2.3 Metastatic Melanoma4.3 Adjuvant Therapy; 4.3.1 Adjuvant Immunotherapy; 4.3.2 Adjuvant Radiation Therapy; 4.4 Chemotherapy; 4.4.1 Alkylating Agents (Dacarbazine/Temozolomide); 4.4.2 Biochemotherapy; 4.5 Targeted Therapy; 4.5.1 BRAFV600E Inhibitors; 4.5.2 MEK Inhibitors; 4.6 Immunotherapy; 4.7 Recommendations (2013)€from Society of Immunotherapy of Cancer for Stage IV Melanoma; References; Tumor Immunology; 5 Overview of Immune System; Abstract; 5.1 Introduction; 5.2 Innate Immune System; 5.2.1 Neutrophils; 5.2.2 Complement System; 5.2.3 Eosinophils; 5.2.4 Mast Cells.
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