Tóm tắt

Herein, we report the bioactivity of monodispersed nanosized reduced graphene oxide (RGO) enfolded goldrnnanoparticles (AuNPs) engineered polycaprolactone (PCL) based electrospun composite scaffolds. The 2D pat-terns of PCL based nanofibers prepared by the homogenous distribution of RGO-AuNPs exhibited unique to-pological and biological features such as mechanical properties, porous structure, large surface area, highrnelectrical conductivity, biodegradability, and resemble the natural extracellular matrix (ECM) that supports thernadhesion, growth, proliferation, and differentiation of stem cells. The prepared composite nanofibers basedrnscaffolds containing RGO-AuNPs accelerated neuronal cell functions and confirmed that the optimized con-centration showed cytocompatibility to PC12 and S42 cells. The 0.0005 wt% loading of RGO-AuNPs on PCL hasrna huge impact on neurite growth which leads to an almost one-fold increase in neurite length growth. Thernpresent study provides a new strategic design of highly efficient scaffolds that have a significant direct impact onrncell activity and could be a potential bioimplant for peripheral nerve repair.