Tóm tắt

In the present work, the biomedical as-cast pure Mg, Mg–1Ca and Mg–2Sr alloys were processed with equalrnchannel angular pressing (ECAP) technique to develop ultrafine microstructure within the materials, and theirrnmicrostructures, mechanical properties, degradation behavior, cytocompatibility in vitro and biocompatibility inrnvivo were studied comprehensively. Finer-gained microstructures and improved mechanical properties of thesernthree materials after ECAP were confirmed compared to their as-cast counterparts. Moreover, after ECAP therndegradation rate of pure Mg was increased while that of Mg–1Ca or Mg–2Sr alloys decreased compared to the ascastrncounterparts. Additionally, good in vitro cytocompatibility and in vivo biocompatibility of these three materialsrnwere revealed by cell cultural tests using osteoblastic MC3T3-E1 and human mesenchymal stem cellsrn(hMSC) and in vivo animal tests at the lateral epicondyle of SD-rats’ femur. This study offers an alternativernpowerful avenue to achieve good comprehensive properties of magnesium-based biodegradable metals. It mightrnalso help to extend the applied range of magnesium-based biodegradable metals in orthopedic field.