Tóm tắt

Current outbreaks associated with drug-resistant clinical strains are demanding for the development of broad-spectrum antibacterial agents. The bactericidal materials should be eco-friendly, economical and effective tornsuppress bacterial growth. Thus, in this work, diameter controlled spherical Cucore-Agrnshell nanoparticlesrn(Ag@CuNPs) with diameter ranging from 70 to 100 nm by one-step co-reduction approach were designed andrnsynthesized. The Ag@CuNPs were homogenous, stable, and positively charged. The 70 nm Ag@CuNPs showed arnconsistent and regular Ag shielding. We observed the 100 nm Ag@CuNPs achieved symmetrical doped Agrnclusters on the Cu core surface. We used Gram-positive and Gram-negative models strains to test the wide-spectrum antibacterial activity. The Ag@CuNPs showed detrimental microbial viability in a dose-dependentrnmanner; however, 70 nm Ag@CuNPs were superior to those of 100 nm Ag@CuNPs. Initially, Ag@CuNPs at-tached and translocated the membrane surface resulting in bacterial eradication. Our analyses exhibited thatrnantibacterial mechanism was not governed by the bacterial genre, nonetheless, by cell type, morphology,rngrowing ability and the NPs uptake capability. The Ag@CuNPs were highly tolerated by human fibroblasts,rnmainly by the use of starch as glucosidic capper and stabilizer, suggesting optimal biocompatibility and activity.rnThe Ag@CuNPs open up a novel platform to study the potential action of bimetallic nanoparticles and theirrnmolecular role for biomedical, clinical, hospital and industrial-chemical applications.