Tóm tắt

Many features that are appropriate for an ideal tissue engineered biomaterial are found in plant tissues.rnHierarchically organizedBambusa vulgarisexhibits structural similarities to native bone, but the degradation ofrncellulose that is the main component of the plant cell wall is a challenge. In this study,Bamboostem wasrnsubjected to decellularization followed by a chemical oxidation process (treated with sodium periodate) tornenhance biocompatibility and biodegradation. The crystallinity of oxidised plant scaffolds was reduced, resultingrnin lower mechanical strength. In contrast, hydrophilicity was enhanced in those scaffolds. In vitro studies de-monstrated better mesenchymal stem cell adhesion, viability, and osteogenic differentiation on oxidized scaf-folds. Those scaffolds also induced angiogenesis, biocompatibility, and biodegradation when implanted sub-cutaneouslyin vivo. Hence, the present study demonstrated the usefulness of “oxidized decellularized plant” asrnbone scaffold for non-load-bearing applications.