Tóm tắt

Developing a facile and scalable synthetic route is important to explore the potential application of functionalrncellulose sponges. Here, a simple and efficient strategy to produce porous and hydrophilic cellulose spongesrnusing surfactant and pore-foaming agent is demonstrated. The obtained cellulose sponges exhibit high waterrnabsorption capacity and rapid shape recoverability. The introduction of chitosan endows the chitosan/celluloserncomposite sponge with good mechanical properties. Inhibitory effects onEscherichia coli, Staphylococcus aureus,rnandPseudomonas aeruginosaare particularly proved. Besides, the result of the dynamic whole blood clotting timernindicated that the chitosan/cellulose composite sponge has better coagulation ability than those of traditionalrngauze and gelatin sponge. Animal experiment further showed that rapid hemostasis within 105 s could bernreached with the composite sponge. Good biocompatibility of the composite sponge is proved by the results ofrnhemocompatibility and cytotoxicity, indicating an excellent candidate as a rapid hemostatic material.