Tóm tắt

Wound dressings have undergone continuous and substantial evolution over time. Modern bandage materials rnconstitute of electrospun biopolymers that enable rapid and effective wound healing due to the high surface area rnto volume ratio of the electrospun nanofibers and their porous structure. In the present study, nanofibrous rnbandages, containing a blend of starch-thermoplastic polyurethane (TPU), were developed by using the elec-trospinning technique. The electrospun nanofibrous mats were subsequently crosslinked with varying con-centrations of glutaraldehyde in order to increase their water stability and mechanical properties. The nanofi-brous bandages were characterized for their structural properties using SEM, FTIR, TGA, DSC, as well as for their rnwater retention ability, water vapor transmission rate (WVTR), tensile strength and blood clotting efficiency. rnCytotoxicity of the bandages was evaluated using human dermal fibroblast cells. Furthermore, the extent of rnwound healing enabled by the nanofibrous bandage was ascertained using Sprague-Dawley rats. The results rnrevealed that the starch-TPU nanofibrous bandages facilitated enhanced wound-healing, as compared to the rntraditional dressing material, such as the cotton gauze.