Tóm tắt

Kyphoplasty is an effective minimally invasive surgical treatment of osteoporotic vertebral compression frac-tures. Current problems associated with kyphoplasty require better injectable bone cements with improvedrnbiodegradability and osseointegrative property as an alternative to polymethyl methacrylate (PMMA) bonerncement. Calcium phosphate cements (CPCs) possess superior biodegradability and osteoconductivity but inferiorrninjectability and mechanical strengths, rendering them unsuitable for kyphoplasty applications. Our previousrnstudies developed a corn starch-reinforced CPC with improved handling, injectable and mechanical properties,rnyet for kyphoplasty applications the reinforced CPC needs to have radiopacity and further enhanced mechanicalrnstrength. This work therefore developed a CPC-Starch-BaSO4 (CSB) system and investigated the effects ofrnradiopaque agent BaSO4on injectability, radiopacity, mechanical and biocompatibility properties of the system.rnResults showed that the addition of BaSO4significantly improved radiopacity and mechanical strengths of CPCrncement. In addition,in vitroevaluations including apoptosis, hemolysis and endotoxin tests andin vivoevaluationrnof subcutaneous implantation all revealed that CSB was biocompatible. This study demonstrates that CSB couldrnmeet the clinical requirements for minimally invasive surgery and thus have great potential for kyphoplastyrnapplications.